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If and when it receives FDA approval, the labeling will almost certainly adopt identical thresholds

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Although there are no randomized controlled trials comparing aromatase inhibitors with traditional medical therapy for endometriosis, pilot studies using aromatase inhibitors with add-back progestins or OCPs have demonstrated significant reduction in endometriosis-associated pelvic pain (37)

GSH production is supported by NRF2 through controlling several enzymes responsible for GSH synthesis, such as the glutamate-cysteine ligase (GCL) complex composed of two subunits, the modifier (GCLM) subunit and the catalytic (GCLC) subunit, which catalyze the rate-limiting step of GSH synthesis that converts cysteine and glutamate into GSH [22]